Endocrine Abstracts

Objectives: Primary aldosteronism (PA) is considered to be the most common cause of secondary hypertension. Therefore, a relevance of early diagnosis of PA is obvious.Methods: We evaluated 98 patients with hypertension in age 47.8±1.4 years. We measured serum potassium by indirect porentiometry, serum aldosterone and plasma rennin activity (PRA) by RIA, serum corticosterone (B), 18-hydroxycorticosterone (18-OH-B), 11-deoxycorticosterone (DOC), 11-de...

BackgroundThe aim of the study was to evaluate urine steroid metabolomics by gas chromatography–mass spectrometry (GC–MS) for the adrenocortical carcinoma (ACC) metastases` biomarkers detection in patients after the surgery.Patients and methods33 postoperative ACC patients were examined before and after the surgery. The median age was 47 years (41–60). The Weiss score was more than 3 points acc...

Background of studyPCOS is a heterogeneous disease characterized by endocrine, metabolic and reproductive disorders. PCOS plays an essential role among the causes of chronic anovulation, menstrual irregularities, hirsutism and anovulatory infertility. Diagnostic problems appear to be extremely urgent due to the wide range of clinical and laboratory manifestations. The study of urine steroid profile by gas chromatography-mass spectrometry will improve the...

Background: The aim of the study was to evaluate urine steroid profiles by gas chromatography–mass spectrometry (GC–MS) in patients with adrenocortical carcinoma (ACC) to assess therapy efficacy.Patients and Methods: 39 ACC patients were examined before and after treatment. The median age was 47 years (41–60). The Weiss score was no less than 4 points. 10 patients were disease-free in the early postoperative period (up to 12 months after s...